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Sabrina Sabatini Giovanni Armenise-Harvard Career Development Awardee
Via dei Sardi 70 00185 Roma 0039 06 49917916 0039 06 49917594 sabrina.sabatini@uniroma1.it |
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Laurea
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Università di Roma La Sapienza 7
July 1994
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Post-embryonic growth and development in higher
plants occurs from localized regions called meristems. Important
developmental decisions, affecting cell division and cell fate
determination, are taken in the meristems, which give rise to adult
structures of the plant, like shoots and roots. Two hormones,
auxin and cytokinin¬, have long been recognized as crucial signaling
molecules controlling shoot and root meristem activity. They are
believed to act synergistically and antagonistically during shoot and
root organogenesis by controlling fundamental developmental processes
such as cell fate decision, cell division and cell polarity. Classic in
vitro plant tissue culture experiments demonstrated that both auxin and
cytokinin are required to induce cell division and that different
auxin-cytokinin ratios lead either to root or shoot formation. However,
little is understood concerning the in vivo significance of these tissue
culture experiments and the mechanisms by which the two hormones act in
concert to exert these effects. In addition to this complexity, the mode
of interaction between auxin and cytokinin is often dependent upon the
plant species and organ being studied. This has hampered, so far, the
establishment of a general model for the control of plant growth and
development by these hormones. |
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Francisco Scaglia Linhares Post doc Raffaele dello Ioio, Phd student Cristina Llavata Master class student Emanuele Scacchi Master class student
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Dello Ioio R., Scaglia Linhares F., Scacchi E., Casamitjana-Martinez E., Heidstra R., Costantino P., Sabrina Sabatini. Citokinins controll root meristem size by controlling cell differentiation. Current Biology in press (2007)
Sabatini S., Heidstra R., Scheres B: Scarecrow is involved in positioning the stem cell niche in the Arabidopsis root meristem. Gene & Development 17, 354-358, (2003).
Sabatini S., Beis D., Wolkenfelt H., Murfett J., Guilfoyle T., Malamy J., Benfey P., Leyser O., Bechtold N., Weisbeek, P. and Scheres, B. An Auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. Cell 99, 463-472, (1999).
Papi M., Sabatini S., Altamura M.M., Hennig L., Schafer E., Costantino P., Vittorioso P. Inactivation of the Phloem-specific Dof Zinc Finger gene DAG1 affects response to light and integrity of the Testa of Arabidopsis seeds. Plant Physiology, 128, 411-417, (2002).
Sabatini S., Papi M., Bouchez D., Camilleri C., Costantino P., Vittorioso P. Identification and disruption of an Arabidopsis zinc finger gene controlling seed germination. Gene & Development 14, 28-33, (2000).
De Paolis A., Sabatini S., De Pascalis L., Costantino P., Capone I.. A rolB regulatory factor belongs to a new class of single zinc finger plant proteins. The Plant Journal 10(2), 215-223, (1996).
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Mechanisms involved in the relation between cell identity and cell proliferation control in the Arabidopsis thaliana root meristem. Major: Developmental Biology, Molecular biology, Cell Biology, Genetic.
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